Science behind weight loss injections
Weight loss injections have revolutionised the way we manage obesity and weight-related health issues. These treatments are scientifically and clinically proven to help individuals lose weight safely and effectively. The most commonly used weight loss injections, such as Wegovy/Ozempic (Semaglutide), and Mounjaro (Tirzepatide), work by mimicking natural hormones in the body that regulate hunger, digestion, and metabolism.
At the core of these injections is a biological mechanism involving GLP-1 (Glucagon-Like Peptide-1), a naturally occurring hormone that plays a critical role in appetite control and blood sugar regulation. Understanding how GLP-1 works is key to understanding why these weight loss injections are so effective.
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What is GLP?
GLP (Glucagon-Like Peptide) refers to a group of hormones that are part of the incretin system—a set of hormones that help regulate metabolism, insulin secretion, hunger and digestion. The two primary types of GLP are:
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GLP-1 (Glucagon-Like Peptide-1) – Key in appetite suppression and blood sugar regulation
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GLP-2 (Glucagon-Like Peptide-2) – Mainly involved in gut health and nutrient absorption
When discussing weight loss injections, GLP-1 is the primary focus, as it plays a vital role in controlling hunger, digestion, and fat storage.
What is GLP-1?
GLP-1 is a natural hormone released by the intestines after eating. It helps regulate several key functions in the body, including:
Appetite control & hunger suppression
GLP-1 communicates with the brain’s appetite centers to reduce hunger and increase feelings of fullness. This helps individuals consume fewer calories without feeling deprived.
Slowing down digestion
GLP-1 delays gastric emptying, meaning food stays in the stomach longer. This leads to prolonged satiety and prevents overeating.
Blood sugar regulation
GLP-1 stimulates insulin release and reduces excess glucose production by the liver. This helps keep blood sugar levels stable, preventing energy crashes and sugar cravings.
Fat storage and energy balance
By reducing calorie intake and controlling insulin levels, GLP-1 helps the body use stored fat for energy, promoting gradual and sustainable weight loss.
How Do GLP-1 Weight Loss Injections Work?
GLP-1 receptor agonists like Semaglutide (Wegovy/Ozempic) and Tirzepatide (Mounjaro) mimic the effects of natural GLP-1, enhancing the body's ability to:
✔ Suppress appetite by interacting with brain receptors
✔ Slow digestion to keep you full for longer
✔ Regulate blood sugar levels and prevent cravings
✔ Encourage fat loss by optimizing insulin function
These injections enhance and extend the effects of natural GLP-1, providing long-lasting appetite control and metabolic benefits.
Scientific evidence supporting GLP-1 weight loss injections
Numerous clinical trials have confirmed the effectiveness of GLP-1 receptor agonists for weight loss:
A 2021 study published in the New England Journal of Medicine found that participants using Semaglutide (Wegovy) lost an average of 15% of their body.
Mounjaro (Tirzepatide) clinical trials demonstrated that individuals obtained a superior weight loss of 20.9%.
GLP-1 receptor agonists have also been shown to improve insulin sensitivity, reduce inflammation, and lower the risk of obesity-related diseases such as type 2 diabetes and heart disease.
Benefits of GLP-1 weight loss injections
✔ Clinically proven to aid in weight loss
✔ Non-surgical and minimally invasive
✔ Helps reduce hunger & cravings
✔ Improves blood sugar control
✔ Supports long-term weight management
Who can benefit from GLP-1 weight loss injections?
These injections are most suitable for individuals who:
✔ Have a BMI of 27+ with weight-related health conditions (e.g., diabetes, high blood pressure)
✔ Struggle with hunger and cravings despite diet and exercise efforts
✔ Are looking for a clinically proven and medically supervised weight loss option
✔ Prefer a non-surgical weight loss treatment
Are GLP-1 injections safe?
Weight loss injections like Wegovy, Ozempic, and Mounjaro are approved as medically supervised treatments. However, they may not be suitable for everyone. Potential side effects include:
⚠ Nausea, vomiting, and digestive discomfort – Common in the first few weeks but usually improves over time
⚠ Low blood sugar (Hypoglycemia) – More common in individuals with diabetes
⚠ Mild injection site reactions – Redness or swelling may occur
⚠ Rare risks – Pancreatitis, gallbladder issues, or thyroid concerns (should be monitored by a doctor)
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This is my seventh week taking the weight loss treatment and i'm astonished with my weight loss. I've dropped from 113kg to 96.5kg. To say I am delighted is an understatement. Thank you so much Liz, your advice has been invaluable. Worth every penny.
Shey Davies, December 2024